Cryogenic electron microscopy (cryo-EM) has now been widely used for determining multichain protein complexes. However, modeling a large complex structure, such as those with more than ten chains, is ...

Single-particle cryo-electron microscopy (cryo-EM) has emerged as a powerful means in modelling macromolecular structures at near-atomic resolution (3–5 Å) 1. While high-resolution density maps enable ...